Finding Better Ways To Cope With Depression
Many people face the problem of depression, usually, at least, once in their lives. Handling depression can be somewhat difficult, as people feel trapped with their feelings of sadness and despair. However, no matter how impossible it may seem, depression can be faced. The tips in this article can help you face depression.
A great tip that can help you fight depression is to make sure you're eating a healthy diet. If you're getting in poor nutrition, you might become tired and sluggish. This can lead to depression. Eating healthy can go a long way in helping you get out of your depression.
A great tip that can help you out of your depression is to consider taking an antidepressant. These will also increase your level of happiness. There are different types of antidepressants, so experiment to find out which one will work best for you.
Try to get outside as much as you can, when suffering from depression. Even if it is just for a quick walk every day, getting some sun and fresh air, can make a world of a difference for controlling depression symptoms. Sitting inside all the time, will just make you feel worse.
Just as you shouldn't be afraid to tell someone that you are suffering from clinical depression you also shouldn't feel obligated to tell everyone. If you are in a professional environment or any situation where you feel that others may not understand the severity of your situation, feel free to keep quiet.
Avoid caffeinated beverages such as coffee, tea, and soda. Caffeine has been shown to decrease the amount of serotonin in your brain, which can depress your mood. Caffeine will also make you jittery and anxious, adding to your depression. Finally, caffeine can affect your sleep schedules, causing further problems with an already disrupted system.
Acknowledging to yourself that your depression needs to be managed is a positive step. To avoid the temptation of sleeping in late or staying in bed throughout the day, purposely schedule appointments before noon to get you up and ready for the day. Always try to schedule your appointments early. Waiting until you wake up to decide your schedule, may put you at a disadvantage to taking charge of how you spend your day and you may be tempted to remain in bed because of the depression.
A beneficial tip for anyone facing depression is to intentionally take a break from feelings of anger or sadness in order to stop and consider all of the positive things in click here your life. By taking stock of the good things with which you have been blessed, you can shift the focus away from your troubles and lift yourself out of your depression - at least temporarily.
Drink plenty of water. Everyone knows that plenty of water is essential to body health, however, it is also crucial to mental health. Having a good and positive attitude is physically more difficult when you are dehydrated. Dehydration can cause your brain to begin to shut down, causing even a normally happy person to become down.
See your doctor. Not only is depression a real disease on its own, it can also be a symptom of other underlying illnesses. Only your doctor will be able to tell you what type of depression you are suffering from or if your symptoms are caused by another ailment. In addition, while many forms of depression can be treated without medication, it can also be caused by a chemical imbalance in the brain necessitating the use of medication for effective treatment.
Try your best to remain positive. Thinking negatively is something depression sufferers do often. Someone who is depressed never feels good about anything in their life, while someone who is happy tends to push aside any negative thoughts or deal with them head on. Staying positive makes it easier for others to socialize with you so that you're not lonely.
A great way to deal with depression is to be physically active. Exercise is great for your body and mind because it releases natural chemicals in your body that are meant to help you feel better. The improvements in your body will also help you to feel great about yourself and boost your self esteem.
In conclusion, if you follow the tips in this article, you may see improvement in a short amount of time. Give yourself a pat on the back daily for the accomplishments that you have made. Try to cope with depression the best you can by using these easy tips and never give up fighting the disease.
Repetitive Transcranial Magnetic Stimulation Improves Mild Cognitive Impairment Associated with Alzheimer’s Disease in Mice by Modulating the miR-567/NEUROD2/PSD95 Axis
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, and its prevalence is increasing worldwide with the progressive aging of the human population, thus constituting a significant burden to public health and patients’ caregivers.1 One of the symptoms associated with the early development of AD is mild cognitive impairment (MCI), which is attributed to multiple factors, including progressive neuronal loss, reduced levels of several crucial neurotransmitters, and altered forms of synaptic plasticity.2 In contrast to the memory loss in developed AD, MCI generally does not have an important impact on the daily life activity of the patients, and it is only characterized by the progressive decline of cognitive functions.3 Based on the domains influenced by the MCI, this symptom can be classified into several subtypes, including amnesic and non-amnesic forms. In certain cases (12–20%), patients with MCI develop a dementia syndrome; thus, MCI is considered to inevitably progress to fully developed AD over time.4 Currently, the diagnosis of MCI requires the positive expressions of several in vivo biomarkers of AD, including cerebrospinal fluid amyloid-β 1–42, total tau or 181-phosphorylated tau. Furthermore, recent studies have demonstrated that certain non-coding RNAs such as microRNAs (miRNAs/miRs) can also be employed as diagnostic predictors or treatment targets for MCI.
MiRNAs are small non-coding RNAs that regulate the function of different genes by inducing either translational repression or mRNA destabilization of their target mRNA. MiRNAs play key roles in numerous neurobiological processes such as neurodevelopment, neuroplasticity and apoptosis.5 Furthermore, the abnormal expression profiles of certain miRNAs are involved in the development of various neurological deficits, including AD, Parkinson’s disease, amyotrophic lateral sclerosis, and vascular dementia.6–9 The data derived from these studies was also applied to the diagnosis and treatment of MCI pre-AD. In the study performed by Felice et al, the authors identified four dysregulated miRNAs in patients with MCI, of which miR-567 showed the highest fold-change and statistical significance.10 The authors also indicated that the downstream effectors of miR-567, including neurogenin 2 (NEUROG2), transcription factor (TCF) 3, TCF4, and T-box brain transcription factor 1 (TBR1), are likely to contribute to the dysfunction of the nervous system. For example, neuronal differentiation 2 (NEUROD2) is a transcriptional regulator implicated in neuronal differentiation, while TCF3 maintains the neural stem cell population during neocortical development.11,12 Therefore, miR-567-related signaling transduction can represent a potential and promising target for the diagnosis and treatment of MCI associated with AD progression. Thus, therapeutic strategies that modulate the activity of miR-567 can benefit patients with MCI long-term.